8-Bromo-ATP

CAT: 0804-HY-134262Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134262Size:1 mg
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Description
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3].
CAS Number
[23567-97-7]
Product Name Alternative
8-Bromoadenosine 5'-triphosphate; 8-Br-ATP
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-bromo-atp.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O)OP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(Br)=NC3=C(N)N=CN=C23)O1)(O)=O)(O)=O
Molecular Formula
C10H15BrN5O13P3
Molecular Weight
586.08
References & Citations
[1]Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder) . Eur. J. Med. Chem. 23 (5), 433-439 (1988) .|[2]P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263 (25) :12288-94.|[3]Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21 (4) :306-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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