8-Azido-ATP (trisodium)

8-Azido-ATP (trisodium)

• UNSPSC Description: 8-Azido-ATP (8-N3-ATP) trisodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP trisodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP trisodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/8-azido-atp-trisodium.html
• Smiles: O[C@H]1[C@@H](O)[C@H](N2C(N=[N+]=[N-])=NC3=C(N=CN=C32)N)O[C@@H]1COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
• Molecular Weight: 614.14
• References & Citations: [1]S Valenzuela, et al. Photoaffinity labeling of rotavirus VP1 with 8-azido-ATP: identification of the viral RNA polymerase. J Virol. 1991 Jul;65(7):3964-7. |[2]K Tanabe, et al. Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. J Biol Chem. 1999 Feb 12;274(7):3931-3.
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