SCH-202676

CAT: 0804-HY-133862-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-133862-01Size:5 mg
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Description
SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR) . SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].
CAS Number
[70375-43-8]
UNSPSC
12352005
Target
Adenosine Receptor; G protein-coupled Bile Acid Receptor 1; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sch-202676.html
Purity
99.46
Solubility
10 mM in DMSO
Smiles
C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1
Molecular Formula
C15H13N3S
Molecular Weight
267.35
References & Citations
[1]Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129.|[2]Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147 (4) :422-9.|[3]Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59 (1) : 30-37.|[4]Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74 (25) :3173-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A3 receptor (A3R)

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