HyNic-PEG2-TCO

• UNSPSC Description:

  HyNic-PEG2-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. HyNic-PEG2-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hynic-peg2-tco.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C/C(C)=N/NC(C=C1)=NC=C1C(NCCOCCOCCNC(OC2CCC/C=C/CC2)=O)=O

• Molecular Weight:

  475.58

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported