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HyNic-PEG2-DBCO

CAT: 0804-HY-133498-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-133498-01Size:25 mg
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Description
HyNic-PEG2-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. HyNic-PEG2-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
CAS Number
[2741281-12-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hynic-peg2-dbco.html
Purity
98.10
Solubility
10 mM in DMSO
Smiles
C/C(C)=N/NC(C=C1)=NC=C1C(NCCOCCOCCC(NCCC(N2C(C=CC=C3)=C3C#CC(C=CC=C4)=C4C2)=O)=O)=O
Molecular Formula
C34H38N6O5
Molecular Weight
610.70
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

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