Propargyl-PEG4-acid

• Target:

  Others|||PROTAC Linker

• Related Pathways:

  Others|||PROTAC

• Bioactivity:

  Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells[1].

• Smiles:

  C (OCCOCCOCC#C) COCCC (O) =O

• Molecular Formula:

  C12H20O6

• Molecular Weight:

  260.28

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1415800-32-6