DBCO-Val-Cit-OH

DBCO-Val-Cit-OH

• UNSPSC Description: DBCO-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Val-Cit-OH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dbco-val-cit-oh.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)CCCCC(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=O)=O)C(C)C)=O
• Molecular Weight: 589.68
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported