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DBCO- (PEG2-Val-Cit-PAB) 2

CAT: 0804-HY-126676Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126676Size:1 Each
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Description
DBCO- (PEG2-Val-Cit-PAB) 2 is a dual cleavable ADC linker for antibody-drug conjugates (ADCs) . DBCO- (PEG2-Val-Cit-PAB) 2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO- (PEG2-Val-Cit-PAB) 2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-peg2-val-cit-pab-2.html
Solubility
10 mM in DMSO
Smiles
OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN(CCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CO)C=C2)=O)=O)=O)C(CCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)=O)=O)=O
Molecular Formula
C69H94N12O16
Molecular Weight
1347.56
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers; Protease Cleavable Linker

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