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Aβ42-IN-1

CAT: 0804-HY-130609Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-130609Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM) . Aβ42-IN-1 potently reduced Aβ42 levels with an IC50 value of 0.091 μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
CAS Number
2582757-69-3
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-beta-42-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC.[H]Cl
Molecular Formula
C29H27ClN4O2
Molecular Weight
499.00
References & Citations
[1]Sekioka R, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators.Bioorg Med Chem. 2019 Nov 6:115132.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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