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Bafilomycin C1

CAT: 0804-HY-130173Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130173Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases) . Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) [2].
CAS Number
88979-61-7
UNSPSC
12352005
Hazard Statement
H301, H312, H330, H410
Target
Antibiotic; Apoptosis; Bacterial; Fungal; Na+/K+ ATPase
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/bafilomycin-c1.html
Purity
99.9
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
C[C@H]([C@@](C[C@H]([C@@H]1C)OC(/C=C/C(O)=O)=O)(O[C@@H]1C(C)C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]2C)=O)([H])[C@H](/C=C/C=C(C[C@@H]([C@@H]2O)C)\C)OC)C
Molecular Formula
C39H60O12
Molecular Weight
720.89
Precautions
H301, H312, H330, H410
References & Citations
[1]E J Bowman, et al. Bafilomycins: A Class of Inhibitors of Membrane ATPases From Microorganisms, Animal Cells, and Plant Cells. Proc Natl Acad Sci U S A. 1988 Nov;85 (21) :7972-6.|[2]Xiaoxiao Gao, et al.Bafilomycin C1 Induces G0/G1 Cell-Cycle Arrest and Mitochondrial-Mediated Apoptosis in Human Hepatocellular Cancer SMMC7721 Cells. J Antibiot (Tokyo) . 2018 Sep;71 (9) :808-817.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Macrolide

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