Bafilomycin C1

• Description :

  Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases) . Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) [2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H312, H330, H410

• Target :

  Antibiotic; Apoptosis; Bacterial; Fungal; Na+/K+ ATPase

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Apoptosis; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/bafilomycin-c1.html

• Purity :

  99.9

• Solubility :

  DMSO : 5 mg/mL (ultrasonic; warming)

• Smiles :

  C[C@H]([C@@](C[C@H]([C@@H]1C)OC(/C=C/C(O)=O)=O)(O[C@@H]1C(C)C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]2C)=O)([H])[C@H](/C=C/C=C(C[C@@H]([C@@H]2O)C)\C)OC)C

• Molecular Formula :

  C39H60O12

• Molecular Weight :

  720.89

• Precautions :

  H301, H312, H330, H410

• References & Citations :

  [1]E J Bowman, et al. Bafilomycins: A Class of Inhibitors of Membrane ATPases From Microorganisms, Animal Cells, and Plant Cells. Proc Natl Acad Sci U S A. 1988 Nov;85 (21) :7972-6.|[2]Xiaoxiao Gao, et al.Bafilomycin C1 Induces G0/G1 Cell-Cycle Arrest and Mitochondrial-Mediated Apoptosis in Human Hepatocellular Cancer SMMC7721 Cells. J Antibiot (Tokyo) . 2018 Sep;71 (9) :808-817.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Macrolide

• CAS Number :

  [88979-61-7]