Bafilomycin B1

CAT: 0804-HY-N6738-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6738-01Size:1 mg
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Description
Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A) -induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL) -induced accumulation of lipid droplets[1][2][3].
CAS Number
[88899-56-3]
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Antibiotic; Bacterial; Fungal; Proton Pump
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bafilomycin-b1.html
Purity
98.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O
Molecular Formula
C44H65NO13
Molecular Weight
815.99
Precautions
H300+H310+H330
References & Citations
[1]Shacka, J. J., et al., (2006) . Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection. Autophagy, 2 (3), 228–230.|[2]Pivtoraiko, V. N., et al., (2010) . Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of neurochemistry, 114 (4), 1193–1204.|[3]Naganuma, S., et al., (1992) . Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E. Biochimica et biophysica acta, 1126 (1), 41–48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Macrolide

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