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(S) -GNE-987

CAT: 0804-HY-129937Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129937Size:1 Each
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Description
(S) -GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S) -GNE-987 binds to the BRD4 BD1 (IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC) [1].
CAS Number
2738533-33-8
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-gne-987.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](C[C@H](O)C1)N1C([C@@H](NC(CCCCCCCCCCNC(C2=C(CS(=O)(C)=O)C=C(C(N(C3=NC=C(F)C=C3F)C4)=C2)C5=CN(C)C(C6=C5C4=CN6)=O)=O)=O)C(C)(C)C)=O)NCC7=CC=C(C(SC=N8)=C8C)C=C7
Molecular Formula
C56H67F2N9O8S2
Molecular Weight
1096.31
References & Citations
[1]Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; von Hippel-Lindau (VHL)

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CatalogName
MBS5753210GNE-987
A23927-10GNE-987 10mg
A23927-1GNE-987 1mg
A23927-50GNE-987 50mg
T12798-01(S) -GNE-987
MBS5767545(S)-GNE-987
A23927-5GNE-987 5mg
sc-481117AOI 987
sc-200187APNU-282,987
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