GS-389

• Description :

  GS 389 ((±) -O, O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].

• Product Name Alternative :

  (±) -O, O-Dimethylcoclaurine

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/gs-389.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=C(CC2NCCC3=C2C=C(OC)C(OC)=C3)C=C1

• Molecular Formula :

  C19H23NO3

• Molecular Weight :

  313.39

• References & Citations :

  [1]Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72 (4) :327-334.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [41498-37-7]