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(-) -Eseroline (fumarate)

CAT: 0804-HY-129101-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129101-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Eseroline fumarate is a metabolic of Physostigmine , an AChE inhibitor. (-) -Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-) -Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-) -Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2].
CAS Number
70310-73-5
Product Name Alternative
Eseroline (fumarate)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/minus-eseroline-fumarate.html
Solubility
10 mM in DMSO
Smiles
OC(/C=C/C(O)=O)=O.C[C@]12C3=CC(O)=CC=C3N([C@@]1([H])N(CC2)C)C
Molecular Formula
C17H22N2O5
Molecular Weight
334.37
References & Citations
[1]Somani SM, et al. Eseroline, a metabolite of physostigmine, induces neuronal cell death. Toxicol Appl Pharmacol. 1990 Oct;106 (1) :28-37. |[2]Bartolini A, et al. Eseroline: a new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents. Neurosci Lett. 1981 Sep 1;25 (2) :179-83. |[3]Harris LS, et al. Narcotic-antagonist analgesics: interactions with cholinergic systems. J Pharmacol Exp Ther. 1969 Sep;169 (1) :17-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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