Products for Research Use Only
RegisterLogin

Dofequidar (fumarate)

CAT: 0804-HY-17013A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-17013A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dofequidar fumarate (MS-209) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1) . Dofequidar fumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect[1][2].
CAS Number
153653-30-6
Product Name Alternative
MS-209
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dofequidar-fumarate.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)
Smiles
OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC3.O=C(O)/C=C/C(O)=O
Molecular Formula
C34H35N3O7
Molecular Weight
597.66
Precautions
H315, H319, H320
References & Citations
[1]Nokihara H, et al. A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells. Jpn J Cancer Res. 2001 Jul;92 (7) :785-92.|[2]Katayama R, et al. Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci. 2009 Nov;100 (11) :2060-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Related Products

CatalogName
HY-17013-01Dofequidar
HY-17013DDofequidar (sesquifumarate)
HY-B1562CBopindolol (fumarate)
HY-12300B-01Ocifisertib (fumarate)
HY-136842Oxetorone (fumarate)
HY-129305Tampramine (fumarate)
HY-112280A-01Crozbaciclib (fumarate)
HY-106018AMitemcinal (fumarate)
HY-106019BLiarozole (fumarate)
HY-143216A-01Ensitrelvir (fumarate)

Alternative Products

CatalogName
B1167-10Dofequidar fumarate
TQ0043-01Dofequidar
A22042-5Dofequidar 5mg
A22042-25Dofequidar 25mg
A22042-10Dofequidar 10mg
A22042-1Dofequidar 1mg
MA-0233Fumarate
TBI4578-5MGFumarate hydratase-IN-1, Fumarate hydratase inhibitor
B1490-50Quetiapine Fumarate
B3491-5Bedaquiline fumarate

Popular Products