Mcl1-IN-9

Mcl1-IN-9

• CAS Number: 1810769-31-3
• UNSPSC Description: Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mcl1-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=CC=CC(C5=C(C)N(C)N=C5C)=C4N2CCCN1CC6=CC=CC(C(O)=O)=C6
• Molecular Weight: 639.18
• References & Citations: [1]Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported