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Mcl1-IN-15

CAT: 0804-HY-W286906Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W286906Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity[1].
CAS Number
518303-27-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(O)CSC1=CC(NS(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)=C3C=CC=CC3=C1O
Molecular Formula
C22H23NO5S2
Molecular Weight
445.55
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Abulwerdi FA, et al., 3-Substituted-N- (4-hydroxynaphthalen-1-yl) arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem. 2014 May 22;57 (10) :4111-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1

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