Autogramin-1

• Description :

  Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy

• Type :

  Reference compound

• Related Pathways :

  Autophagy

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/autogramin-1.html

• Purity :

  99.79

• Solubility :

  DMSO : 6.94 mg/mL (ultrasonic)

• Smiles :

  O=C(N1)N(CCC)C(C2=C1C=C(C(NC3=NC(CCN(C(OC(C)(C)C)=O)C4)=C4S3)=O)C=C2)=O

• Molecular Formula :

  C23H27N5O5S

• Molecular Weight :

  485.56

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15 (7) :710-720.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2375541-73-2]