Autogramin-2

• UNSPSC Description:

  Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM)[1].

• Target Antigen:

  Autophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/autogramin-2.html

• Purity:

  99.53

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=NC(CCN(C(OC(C)(C)C)=O)C2)=C2S1)C3=CC=C(OC(C)C)C=C3

• Molecular Weight:

  417.52

• References & Citations:

  [1]Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15(7):710-720.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2375541-45-8