GF 15

• Description:

  GF 15 is an inhibitor of centrosomal clustering during cell mitosis, with an EC50 value of 900 nM for inducing multipolar spindles. GF 15 is a derivative of griseofulvin that inhibits tubulin polymerization at concentrations above 25 μM. GF 15 inhibits tumor growth and significantly prolongs survival in mouse xenograft models of human colon cancer and multiple myeloma[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H335

• Target:

  Microtubule/Tubulin; Mitosis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GF_15.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1[C@]2(C(OCC3=CC=CC=C3)=CC(C[C@H]2C)=O)OC4=C(Cl)C(OC)=CC(OC)=C14

• Molecular Formula:

  C23H21ClO6

• Molecular Weight:

  428.86

• Precautions:

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations:

  [1]Raab MS, et al. GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 2012 Oct 15;72 (20) :5374-85.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [888042-13-5]