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Methylpiperidino pyrazole

CAT: 0804-HY-127133Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-127133Size:1 Each
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Description
Methylpiperidino pyrazole (MPP) is a potent and selective ER (estrogen receptor) modulator. Methylpiperidino pyrazole induces significant apoptosis in the endometrial cancer and oLE cell lines. Methylpiperidino pyrazole reverses the the positive effects of beta-estradiol. Methylpiperidino pyrazole has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3].
CAS Number
289726-02-9
Product Name Alternative
MPP
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/methylpiperidino-pyrazole.html
Solubility
10 mM in DMSO
Smiles
CC1=C(N(N=C1C2=CC=C(C=C2)O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5
Molecular Formula
C29H31N3O3
Molecular Weight
469.57
References & Citations
[1]Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167) . Nutrients. 2018 May 25;10 (6) . pii: E672.|[2]Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl) . 2015 Aug;232 (16) :2981-94.|[3]Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73 (8) :1034-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Biochem Pharmacol. 2024 May 9:225:116256.|Food Chem Toxicol. 2023 Jun:176:113792.|J Pharm Anal. 2025 Jul;15 (7) :101182.|Biochem Pharmacol. 2025 Dec;242 (Pt 4) :117432.|Biol Reprod. 2025 Jun 15;112 (6) :1114-1122.|Metab Brain Dis. 2022 Oct;37 (7) :2349-2362.|Biomolecules. 2023 Jul 10;13 (7) :1097.|Drug Resist Updat. 2023 Nov:71:101014.|Ecotoxicol Environ Saf. 2023 Jul 1:259:115060.|Eur J Inflamm. October 11, 2021.|Mol Nutr Food Res. 2021 Sep;65 (17) :e2100070.|Phytomedicine. 2022 May:99:154022.|Phytomedicine. 2024 Jan:123:155218.

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