Phthalazinone pyrazole
CAT:
804-HY-12564-06
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Phthalazinone pyrazole
- CAS Number: 880487-62-7
- UNSPSC Description: Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells[1][2].
- Target Antigen: Apoptosis; Aurora Kinase
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/phthalazinone-pyrazole.html
- Purity: 98.0
- Solubility: DMSO : ≥ 11.11 mg/mL
- Smiles: O=C1C2=CC=CC=C2C(NC3=NNC(C)=C3)=NN1C4=CC=CC=C4
- Molecular Weight: 317.34
- References & Citations: [1]Prime ME, et al. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase. J Med Chem. 2011;54(1):312-319. |[2]Choi YJ, et al. Phthalazinone Pyrazole Enhances the Hepatic Functions of Human Embryonic Stem Cell-Derived Hepatocyte-Like Cells via Suppression of the Epithelial-Mesenchymal Transition. Stem Cell Rev Rep. 2018;14(3):438-450.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported