1H-pyrazole

• Description:

  1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities[1][2][3][4].

• Product Name Alternative:

  Pyrazole

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H311, H315, H318, H373, H412

• Target:

  Biochemical Assay Reagents; Drug Intermediate

• Type:

  Natural Products

• Related Pathways:

  Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/1h-pyrazole.html

• Purity:

  99.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  N1=CC=CN1

• Molecular Formula:

  C3H4N2

• Molecular Weight:

  68.08

• Precautions:

  H302, H311, H315, H318, H373, H412

• References & Citations:

  [1]Bekhit AA, et al. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. Eur J Med Chem. 2008 Mar;43 (3) :456-63.|[2]Vyas KM, et al. Synthesis, spectroscopic characterization and DNA nuclease activity of Cu (II) complexes derived from pyrazolone based NSO-donor Schiff base ligands. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Dec 15;84 (1) :256-68.|[3]Jhuang J Y, et al. Adsorption and reaction pathways of 1H-pyrazole on Cu (100) and O/Cu (100) . The Journal of Physical Chemistry C, 2018, 122 (11) : 6195-6208.|[4]Bekhit AA, et al. Evaluation of some 1H-pyrazole derivatives as a dual acting antimalarial and anti-leishmanial agents. Pak J Pharm Sci. 2014 Nov;27 (6) :1767-73. PMID: 25362601.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [288-13-1]