K-80003

• Description:

  K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.

• Product Name Alternative:

  TX-803

• UNSPSC:

  12352005

• Target:

  Akt

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/K-80003.html

• Concentration:

  10mM

• Purity:

  99.16

• Solubility:

  DMSO : 30 mg/mL (ultrasonic)

• Smiles:

  CC1=C(C2=CC(F)=CC=C2/C1=C(C3=CC=C(C=C3)C(C)C)/[H])CC(O)=O

• Molecular Formula:

  C22H21FO2

• Molecular Weight:

  336.40

• References & Citations:

  [1]Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17 (6) :560-73.|[2]Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα. Nat Commun. 2017 Jul 17;8:16066.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1292821-90-9]