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K-80003

CAT: 0804-HY-U00458-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00458-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.
CAS Number
1292821-90-9
Product Name Alternative
TX-803
UNSPSC
12352005
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/K-80003.html
Concentration
10mM
Purity
99.16
Solubility
DMSO : 30 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC(F)=CC=C2/C1=C(C3=CC=C(C=C3)C(C)C)/[H])CC(O)=O
Molecular Formula
C22H21FO2
Molecular Weight
336.40
References & Citations
[1]Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17 (6) :560-73.|[2]Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα. Nat Commun. 2017 Jul 17;8:16066.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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