HM03

CAT: 0804-HY-125974-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-125974-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].

CAS Number

500565-15-1

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hm03.html

Purity

99.51

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5

Molecular Formula

C26H27ClN4O2

Molecular Weight

462.97

References & Citations

[1]Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23 (10) :3044‐3050.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HSPA5

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