Ivermectin B1b

• Description :

  Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].

• UNSPSC :

  12352005

• Target :

  Parasite; SARS-CoV

• Type :

  Natural Products

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ivermectin-b1b.html

• Purity :

  98.66

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC([C@H]1O[C@]2(CC[C@@H]1C)C[C@](O3)([H])C[C@](C/C=C([C@H]([C@H](/C=C/C=C4[C@@]5(O)[C@](C=C(C)[C@@H](O)[C@@]5([H])OC/4)([H])C3=O)C)O[C@@]6([H])C[C@@H]([C@@H](O[C@@]7([H])C[C@@H]([C@@H](O)[C@H](C)O7)OC)[C@H](C)O6)OC)\C)([H])O2)C

• Molecular Formula :

  C47H72O14

• Molecular Weight :

  861.07

• References & Citations :

  [1]Katz N, et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. J Antibiot (Tokyo) . 2017;70 (5) :680-684.|[2]Bray M, et al. Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. Antiviral Res. 2020;178:104805.|[3]Demeler J, et al. Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. Parasitology. 2014;141 (7) :948-956.|[4]Collins T, et al. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. 2010;78 (2) :198-204.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [70209-81-3]