Ivermectin

• Description :

  Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs) . Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import[1][2][3][4]. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[5].

• CAS Number :

  [70288-86-7]

• Product Name Alternative :

  MK-933; CD-5024; K-237

• UNSPSC :

  12352005

• Hazard Statement :

  H300, H311

• Target :

  Antibiotic; Autophagy; Bacterial; Dengue Virus; Flavivirus; HIV; HSV; Mitophagy; Parasite; SARS-CoV

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Autophagy

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Ivermectin.html

• Purity :

  98.28

• Solubility :

  DMSO : 250 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@H](/C(C)=C/C[C@@H]3C[C@H]4C[C@@]5(O[C@]([H])(C(C)C)[C@@H](C)CC5)O3)[C@@H](C)/C=C/C=C6CO[C@@]7([H])[C@]\6(O)[C@H](C(O4)=O)C=C(C)[C@H]7O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O.CO[C@H]8C[C@H](O[C@H]9[C@H](C)O[C@@H](O[C@H](/C(C)=C/C[C@@H]%10C[C@H]%11C[C@@]%12(O[C@]([H])([C@@H](C)CC)[C@@H](C)CC%12)O%10)[C@@H](C)/C=C/C=C%13CO[C@@]%14([H])[C@]\%13(O)[C@H](C(O%11)=O)C=C(C)[C@H]%14O)C[C@@H]9OC)O[C@@H](C)[C@@H]8O

• Molecular Formula :

  C48H74O14

• Molecular Weight :

  875.09

• Precautions :

  H300, H311

• References & Citations :

  [1]Khakh BS, et al. Allosteric control of gating and kinetics at P2X (4) receptor channels. J Neurosci. 1999 Sep 1;19 (17) :7289-99.|[2]Priel A, et al. Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol. 2004 Mar;123 (3) :281-93.|[3]Wagstaff KM, et al. Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Biochem J. 2012 May 1;443 (3) :851-6.|[4]Raza S, et al. Ivermectin Inhibits Bovine Herpesvirus 1 DNA Polymerase Nuclear Import and Interferes with Viral Replication. Microorganisms. 2020 Mar 13;8 (3) . pii: E409.|[5]Khan Sharun, et al. Ivermectin, a New Candidate Therapeutic Against SARS-CoV-2/COVID-19. Ann Clin Microbiol Antimicrob. 2020 May 30;19 (1) :23.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  HIV-1; HSV-1