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PNU-282987 (free base)

CAT: 0804-HY-12560Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12560Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].
CAS Number
711085-63-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor; nAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pnu-282987-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H]1CN2CCC1CC2)C3=CC=C(Cl)C=C3
Molecular Formula
C14H17ClN2O
Molecular Weight
264.75
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48 (4) :905-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Lactoferrin

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