6α-Hydroxy Paclitaxel-d5

CAT: 0804-HY-125348SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125348SSize:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
6α-Hydroxy Paclitaxel-d5 is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1].
CAS Number
[1315376-90-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cancer
Purity
99.31
Solubility
10 mM in DMSO
Smiles
O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)[C@H](O)[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=C(C(=C(C(=C6[2H])[2H])[2H])[2H])[2H])C7=CC=CC=C7)O)=O)C5)[H]
Molecular Formula
C47H46D5NO15
Molecular Weight
874.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Mori D, et al. Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel. Drug Metab Dispos. 2020 May;48 (5) :387-394.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-144149S-013'-p-Hydroxy paclitaxel-d5
HY-125348-016α-Hydroxy paclitaxel
HY-W7404803'-p-Hydroxy paclitaxel-d5-1
HY-B0015S-01Paclitaxel-d5
HY-B0015S1Paclitaxel-d5 (benzoyloxy)
HY-144561S6α,3'-p-Dihydroxy paclitaxel-d5
HY-118714Sα-Hydroxy alprazolam-d5
HY-122508S-01Hydroxy Ebastine-d5
HY-132394S-01Hydroxy Atrazine-d5
HY-115354S4-Hydroxy Alprazolam-d5

Alternative Products

CatalogName
sc-2174066α-Hydroxy Paclitaxel-d5
RM-P812553-016-Alpha-Hydroxy Paclitaxel-D5
MBS6097004-016alpha-Hydroxy Paclitaxel-d5
RM-P812597-016α-Hydroxy Paclitaxel
MF-0048071-016?-hydroxy Paclitaxel
TRC-H948892-0.5MG6alpha-Hydroxy Paclitaxel-d5 (~90%)
TRC-H948897-1MG3'-p-Hydroxy Paclitaxel-d5
TRC-H948890-0.5MG6-Alpha-Hydroxy Paclitaxel (~90%)
sc-2174096α,3'-p-Dihydroxy Paclitaxel-d5
2791716a-Hydroxy Paclitaxel

Popular Products