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7-Deacetylgedunin

CAT: 0804-HY-124941Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124941Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Deacetylgedunin is an activator of Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1 expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro[1].
CAS Number
10314-90-6
UNSPSC
12352005
Target
Keap1-Nrf2; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/7-deacetylgedunin.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@]34[C@]([C@H](C5=COC=C5)OC([C@@]3([H])O4)=O)(CC[C@]1([H])[C@@]6([C@@](C(C)(C(C=C6)=O)C)([H])C[C@H]2O)C)C
Molecular Formula
C26H32O6
Molecular Weight
440.53
References & Citations
[1]Chen JY, et al. 7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling. Oncotarget. 2017 Jul 5;8 (33) :55051-55063.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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