(S) -C33

• Description:

  (S) -C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S) -C33 can be used for central nervous system diseases and diabetes research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/s-c33.html

• Purity:

  99.46

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1

• Molecular Formula:

  C18H20ClN5O

• Molecular Weight:

  357.84

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88 (5) :836-845.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE1; PDE10; PDE2; PDE4; PDE5; PDE9

• CAS Number:

  [2066488-39-7]