(S) -C33

• Description :

  (S) -C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S) -C33 can be used for central nervous system diseases and diabetes research[1].

• CAS Number :

  [2066488-39-7]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/s-c33.html

• Purity :

  99.46

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1

• Molecular Formula :

  C18H20ClN5O

• Molecular Weight :

  357.84

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88 (5) :836-845.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE1; PDE10; PDE2; PDE4; PDE5; PDE9