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PF-4800567 (hydrochloride)

CAT: 0804-HY-12470ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12470ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-4800567 hydrochloride is a potent and selective inhibitor of casein kinase 1 (CK1), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM) . PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways[1].
CAS Number
1391052-28-0
UNSPSC
12352005
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-4800567-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1.[H]Cl
Molecular Formula
C17H19Cl2N5O2
Molecular Weight
396.27
References & Citations
[1]Walton KM, et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330 (2) :430-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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