Products for Research Use Only
RegisterLogin

JNJ-46356479

CAT: 0804-HY-124372Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-124372Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JNJ-46356479 is a selective and orally bioavailable mGlu2 receptor positive allosteric modulator (PAM), with the EC50 of 78 nM. JNJ-46356479 shows active in vivo[1].
CAS Number
1254979-66-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-46356479.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C(F)=C1)N2CCN(CC2)CC3=C(C4=NN=C(N4C=C3)CC5CC5)C(F)(F)F
Molecular Formula
C22H22F5N5
Molecular Weight
451.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Cid JM, et al. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[ (4- (2,4-difluorophenyl) -1-piperazinyl) methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM) . J Med Chem. 2016;59 (18) :8495-8507.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-172194JNJ-3738
HY-P991172JNJ-70218902
HY-113751-01JNJ-39393406
HY-132895JNJ-67569762
HY-118424-01JNJ-55511118
HY-110132-01JNJ-27141491
HY-19917-01JNJ-39220675
HY-123531JNJ 10329670
HY-148240-01JNJ-65355394
HY-111066-01JNJ-37822681

Alternative Products

CatalogName
MBS5777395JNJ-46356479
MBS131356JNJ-63533054 (JNJ63533054; JNJ 63533054)
BA6861-10JNJ-42253432
A4361-50JNJ-1661010
BA6753-5.1JNJ-61432059
BA6849-10JNJ-55308942
C4122-10JNJ-42165279
BA5559-5.1JNJ-40411813
B5553-5JNJ 10397049
B1574-10JNJ-7777120

Popular Products