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JNJ-42314415

CAT: 0804-HY-123743Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123743Size:1 Each
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Description
JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively[1].
CAS Number
1334165-90-0
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-42314415.html
Solubility
10 mM in DMSO
Smiles
CC1=C(N2C(C(N3CCOCC3)=NC=C2)=N1)C4=CC=C(N=C4)CCOC
Molecular Formula
C19H23N5O2
Molecular Weight
353.42
References & Citations
[1]Anton A H P Megens, et al. Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs. J Pharmacol Exp Ther. 2014 Apr;349 (1) :138-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10

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