DI-404

CAT: 0804-HY-122874Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-122874Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

DI-404 is a potent inhibitor of DCN1 with a KKd value of 6.7 nM. DI-404 selectively inhibits neddylation of cullin 3 in a dose-dependent manner[1].

CAS Number

2187412-79-7

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/di-404.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H]1CCOC2=C1C=CC=C2)[C@@H](NC([C@@H](NC([C@@H](NC(CC)=O)CC3=NC4=CC=C(Cl)C=C4S3)=O)C5CCOCC5)=O)CCCCN

Molecular Formula

C35H45ClN6O6S

Molecular Weight

713.29

References & Citations

[1]Zhou H, et al. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2018 Mar 8;61 (5) :1934-1950.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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