Necrostatin-1 (inactive control)

CAT: 0804-HY-121954-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-121954-01Size:1 mg

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Description

Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1. Necrostatin-1 is a potent necroptosis inhibitor[1].

CAS Number

64419-92-7

Product Name Alternative

Nec-1 (inactive control)

UNSPSC

12352005

Target

Necroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/necrostatin-1-inactive-control.html

Purity

99.9

Solubility

DMF : 20 mg/mL (ultrasonic; warming) |DMSO : 14 mg/mL (ultrasonic; warming)

Smiles

O=C(N1)C(CC2=CNC3=CC=CC=C32)NC1=S

Molecular Formula

C12H11N3OS

Molecular Weight

245.30

References & Citations

[1]Degterev A, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May;4 (5) :313-21.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

5-(1H-Indol-3-ylmethyl)-2-thioxo-4-imidazolidinone

CAS Number	64419-92-7
PubChem CID	5371761
IUPAC Name	5-(1H-indol-3-ylmethyl)-2-sulfanylideneimidazolidin-4-one
Molecular Formula	C12H11N3OS
Molecular Weight	245.30
XLogP	1.7
Topological Polar Surface Area	89
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	17
Formal Charge	0
Complexity	347

SMILES

C1=CC=C2C(=C1)C(=CN2)CC3C(=O)NC(=S)N3

InChI

InChI=1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17)

InChIKey

MPLRRPKKFHUEEL-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 64419-92-7

CID: 5371761

Formula: C12H11N3OS

MW: 245.30

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	245.30
XLogP3	1.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	245.06228316
Monoisotopic Mass	245.06228316
Topological Polar Surface Area	89 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	347
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-15760-01	Necrostatin-1
HY-15760R-01	Necrostatin-1 (Standard)
HY-168770-01	Cl-Necrostatin-1
HY-118914-01	Glucagon receptor antagonist inactive control
HY-W319332	Necrostatin-21
HY-124546-01	Necrostatin-5
HY-117200-01	Necrostatin-7
HY-132203-01	Necrostatin-34
HY-14622-01	Necrostatin 2
HY-14622A-01	Necrostatin 2 (racemate)

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Necrostatin-1 (inactive control)

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