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Cl-Necrostatin-1

CAT: 0804-HY-168770-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168770-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO) . Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases[1][2][3].
CAS Number
862377-51-3
UNSPSC
12352005
Target
Apoptosis; RIP kinase; TNF Receptor
Related Pathways
Apoptosis
Field of Research
Cardiovascular Disease
Smiles
O=C1N(C)C(NC1CC2=CNC3=C2C=CC=C3Cl)=S
Molecular Formula
C13H12ClN3OS
Molecular Weight
293.77
References & Citations
[1]Degterev A, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May;4 (5) :313-21. |[2]Teng X, et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15 (22) :5039-44.|[3]Degterev A, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1 (2) :112-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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