Doxorubicinol

• Description :

  Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

• Product Name Alternative :

  Adriamycinol; DXR-OL

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/doxorubicinol.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C2=C(C3=C(C(O)=C2C(C4=C1C=CC=C4OC)=O)[C@@H](O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N)C[C@](O)([C@H](CO)O)C3)O

• Molecular Formula :

  C27H31NO11

• Molecular Weight :

  545.54

• References & Citations :

  [1]Olson RD, et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A. 1988 May;85 (10) :3585-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [54193-28-1]