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(S) -Bromoenol lactone

CAT: 0804-HY-120986Size: 1 mg (3.15 mM x 1 mL in Methyl acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-120986Size:1 mg (3.15 mM x 1 mL in Methyl acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Bromoenol lactone ((S) -BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM[1].
CAS Number
478288-94-7
Product Name Alternative
(S) -BEL; (S, E) -Bromoenol lactone
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-bromoenol-lactone.html
Concentration
3.15 mM * 1 mL in Methyl acetate
Purity
99.1
Solubility
10 mM in DMSO
Smiles
O=C1[C@H](C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br
Molecular Formula
C16H13BrO2
Molecular Weight
317.18
References & Citations
[1]Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277 (36) :32807-14.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Phospholipase A

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