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Bromoenol lactone

CAT: 0804-HY-107411-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107411-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bromoenol lactone ((6E) -Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].
CAS Number
88070-98-8
Product Name Alternative
(6E) -Bromoenol lactone
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bromoenol-lactone.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br
Molecular Formula
C16H13BrO2
Molecular Weight
317.18
Precautions
H315, H319, H335
References & Citations
[1]Fensome-Green A, et al. Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. Cell Calcium. 2007 Feb;41 (2) :145-53.|[2]Takuma T, et al. Role of Ca2+-independent phospholipase A2 in exocytosis of amylase from parotid acinar cells. J Biochem. 1997 Jun;121 (6) :1018-24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Phospholipase A

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