Heptelidic acid

Heptelidic acid

• CAS Number: 57710-57-3
• UNSPSC Description: Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].
• Target Antigen: Antibiotic; Caspase
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/heptelidic-acid.html
• Purity: 97.50
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C[C@@]2([H])[C@]([C@@]3(OC3)CC[C@@H]2C(C)C)([H])C(OC1)=O)O
• Molecular Weight: 280.32
• References & Citations: [1]Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo). 1980 May;33(5):468-73.|[2]Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19(8):787-91.|[3]Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.e8.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported