Cryptochlorogenic acid

• Description:

  Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-κB activity, promoting Nrf2 nuclear transfer, and regulating PI3Kα/Akt/ mTOR / HIF-1α signaling pathway Induced physiological stress response[1][2][3].

• Product Name Alternative:

  4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Keap1-Nrf2; mTOR; NF-κB

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Cryptochlorogenic-acid.html

• Purity:

  99.87

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(/C=C/C1=CC(O)=C(O)C=C1)O[C@@H]([C@@H]2O)[C@@H](C[C@](C(O)=O)(O)C2)O

• Molecular Formula:

  C16H18O9

• Molecular Weight:

  354.31

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Wang Jing, ea al.Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in Xiao′erjinning oral liquid by an HPLC method. China Journal of Chinese Materia Medica, 2010-13|[2]Zhao XL, et al. Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages. Int Immunopharmacol. 2020;83:106436.|[3]Li J, et al. Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway. Food Funct. 2022;13 (4) :2269-2282. Published 2022 Feb 21.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  HIF-1α

• CAS Number:

  [905-99-7]