CYD-2-11

CAT: 0804-HY-120275Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120275Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer[1][2].
CAS Number
[1425944-22-4]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyd-2-11.html
Solubility
10 mM in DMSO
Smiles
NCCOC1=CC=CC=C1/C=C2C3=C(C=CC([N+]([O-])=O)=C3)C4=C/2C=CC=C4
Molecular Formula
C22H18N2O3
Molecular Weight
358.39
References & Citations
[1]Liu G, et al. Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. Eur J Med Chem. 2019 Sep 15;178:589-605.|[2]Li R, et al. Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017 Jun 1;77 (11) :3001-3012. doi: 10.1158/0008-5472.CAN-16-2356. Epub 2017 Apr 5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-123020CYD-2-88
HY-148368CYD-4-61
HY-153953Bcl-2-IN-11
HY-145856VEGFR-2-IN-11
HY-163598HIF-2α-IN-11
HY-160618-0111β-HSD2-IN-2
HY-145988COX-2-IN-11
HY-P3896Substance P (2-11)
HY-168171ERK1/2 inhibitor 11
HY-P5896Ala5-Galanin (2-11)

Alternative Products

CatalogName
M11797-01CYD-2-11
T89358-01CYD-2-88
TRC-B542160-25MGBr7-CyD
TRC-I100060-25MGI7-CyD
MBS3601879CYD-1-79
MBS9017573Rabbit anti-Caenorhabditis elegans cyd-1 Polyclonal Antibody
CYD-50CYD (Check Your Drink) - Drink Spike Test - Drink Safety Test Strip
MBS8246497-01Galanin (2-11)
T85382-0111β-HSD2-IN-2
sc-398966Brn-2 (A-11)

Popular Products