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TAS05567

CAT: 0804-HY-120214Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120214Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC50 of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC50s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively) . TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases[1].
CAS Number
1429038-15-2
UNSPSC
12352005
Target
RET; Syk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tas05567.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(NC2=CC3=CN(C(C)(C)C)N=C3C(C)=C2)N=C(N[C@H]4[C@@H](N)COCC4)N=N1)N
Molecular Formula
C21H29N9O2
Molecular Weight
439.51
References & Citations
[1]Hayashi H, et al. TAS05567, a Novel Potent and Selective Spleen Tyrosine Kinase Inhibitor, Abrogates Immunoglobulin-Mediated Autoimmune and Allergic Reactions in Rodent Models. J Pharmacol Exp Ther. 2018 Jul;366 (1) :84-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19203037-01TAS05567

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