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TAS05567

CAT: 0013-GTR19203037-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203037-02Size:50 mg
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Description
TAS05567 is a potent and highly selective ATP-competitive inhibitor of Syk with an IC50 of 0.37 nM. It demonstrates selectivity, showing significant activity against only four other kinases (FLT3, JAK2, KDR, RET) in a broad panel. This inhibitor is a valuable tool for investigating Syk-dependent signaling pathways in both in vitro and in vivo immunological and oncological research contexts.
CAS Number
1429038-15-2
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
CC=1C=2C (=CN (C (C) (C) C) N2) C=C (NC=3C (C (N) =O) =NN=C (N[C@H]4[C@@H] (N) COCC4) N3) C1
Molecular Formula
C21H29N9O2
Molecular Weight
439.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 71543230
CAS Number1429038-15-2
PubChem CID71543230
IUPAC Name3-[[(3R,4R)-3-aminooxan-4-yl]amino]-5-[(2-tert-butyl-7-methylindazol-5-yl)amino]-1,2,4-triazine-6-carboxamide
Molecular FormulaC21H29N9O2
Molecular Weight439.5
XLogP1.2
Topological Polar Surface Area159
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity660
SMILES
CC1=CC(=CC2=CN(N=C12)C(C)(C)C)NC3=C(N=NC(=N3)N[C@@H]4CCOC[C@@H]4N)C(=O)N
InChI
InChI=1S/C21H29N9O2/c1-11-7-13(8-12-9-30(21(2,3)4)29-16(11)12)24-19-17(18(23)31)27-28-20(26-19)25-15-5-6-32-10-14(15)22/h7-9,14-15H,5-6,10,22H2,1-4H3,(H2,23,31)(H2,24,25,26,28)/t14-,15+/m0/s1
InChIKey
ATERGQQFFHVNOJ-LSDHHAIUSA-N
Chemical Structure
2D Structure
2D structure of CID 71543230
CAS: 1429038-15-2
CID: 71543230
Formula: C21H29N9O2
MW: 439.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight439.5
XLogP31.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass439.24442120
Monoisotopic Mass439.24442120
Topological Polar Surface Area159 Ų
Heavy Atom Count32
Formal Charge0
Complexity660
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5770035TAS05567

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