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Metixene (hydrochloride)

CAT: 0804-HY-120081BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120081BSize:1 Each
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Description
Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride can be used for the research of parkinsonian[1][2][3].
CAS Number
1553-34-0
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/metixene-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CN1CC(CC2C3=C(SC4=C2C=CC=C4)C=CC=C3)CCC1.[H]Cl
Molecular Formula
C20H24ClNS
Molecular Weight
345.93
References & Citations
[1]Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62 (2) :90-4.|[2]J. Hagenah, et al. Exogenous levodopa is not toxic to elderly subjects with non-parkinsonian movement disorders: further clinical evidence. , 106 (3-4), 301–307. doi:10.1007/s007020050159 |[3]S L Levin, et al. Dualism in the effect of cholinolytics upon the human parotid gland deprived of parasympathetic control. Int J Clin Pharmacol Res. 1986;6 (5) :429-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Metixene Hydrochloride
CAS Number1553-34-0
PubChem CID64722
IUPAC Name1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine;hydrochloride
Molecular FormulaC20H24ClNS
Molecular Weight345.9
Topological Polar Surface Area28.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity349
SMILES
CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24.Cl
InChI
InChI=1S/C20H23NS.ClH/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H
InChIKey
RSXZRFHNNTTWCB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Metixene Hydrochloride
CAS: 1553-34-0
CID: 64722
Formula: C20H24ClNS
MW: 345.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass345.1317986
Monoisotopic Mass345.1317986
Topological Polar Surface Area28.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity349
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
FM171063Metixene hydrochloride
TQ0304-01Metixene hydrochloride hydrate
A21844-100Metixene hydrochloride 100mg
A21844-25Metixene hydrochloride 25mg
A21844-1Metixene hydrochloride 1mg
TRC-M338972-500MGMetixene-d3 Hydrochloride
A21844-5Metixene hydrochloride 5mg
A21844-50Metixene hydrochloride 50mg
A21844-10Metixene hydrochloride 10mg
A18028-5Metixene hydrochloride hydrate 5mg

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