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Metixene

CAT: 0804-HY-120081Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120081Size:1 Each
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Description
Metixene (Piperidine) is an anticholinergic and antiparkinsonian agent. Metixene potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene can be used for the research of parkinsonian[1][2][3].
CAS Number
4969-02-2
UNSPSC
12352005
Hazard Statement
H302-H410
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/metixene.html
Solubility
10 mM in DMSO
Smiles
CN1CC(CC2C3=C(SC4=C2C=CC=C4)C=CC=C3)CCC1
Molecular Formula
C20H23NS
Molecular Weight
309.47
Precautions
P264-P270-P273-P330-P391-P501
References & Citations
[1]Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62 (2) :90-4. |[2]J. Hagenah, et al. Exogenous levodopa is not toxic to elderly subjects with non-parkinsonian movement disorders: further clinical evidence. , 106 (3-4), 301–307. doi:10.1007/s007020050159|[3]S L Levin, et al. Dualism in the effect of cholinolytics upon the human parotid gland deprived of parasympathetic control. Int J Clin Pharmacol Res. 1986;6 (5) :429-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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