Y-99

• Description :

  Y-99 is a PORCN inhibitor with an IC50 of 155.4 nM against the Wnt/β-catenin signaling pathway. Y-99 inhibits the expression of p-LRP6, β-catenin, and c-Myc[1].

• UNSPSC :

  12352005

• Target :

  C-Myc; Porcupine; Wnt; β-catenin

• Related Pathways :

  Apoptosis; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C(NCC1=NC(C2CCC(F)(F)CC2)=NO1)C3=NOC(C4=CC=CN=C4)=C3

• Molecular Formula :

  C18H17F2N5O3

• Molecular Weight :

  389.36

• References & Citations :

  [1]Yang X, et al. Discovery and Identification of a Novel PORCN Inhibitor via Structure-Based Virtual Screening. ACS Chem Biol. 2025 Jun 20;20 (6) :1319-1332.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2034334-74-0]