Coelenteramine 400a (hydrochloride)

CAT: 0804-HY-118462ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-118462ASize:1 Each
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Description
Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm[1][2]. Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) [3].
CAS Number
[2320429-05-6]
Product Name Alternative
Coelenterazine 400a (hydrochloride) ; Bisdeoxycoelenterazine (hydrochloride)
UNSPSC
12352005
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/coelenteramine-400a-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CC2=CC=CC=C2)=NC3=C(CC4=CC=CC=C4)NC(C5=CC=CC=C5)=CN31.[H]Cl
Molecular Formula
C26H22ClN3O
Molecular Weight
427.93
References & Citations
[1]Levi J, et, al. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. J Am Chem Soc. 2007 Oct 3;129 (39) :11900-1.|[2]Bertrand L, et, al. The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS) . J Recept Signal Transduct Res. Feb-Nov 2002;22 (1-4) :533-41.|[3]Yuan M L, et al. Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation[J]. Chinese Chemical Letters, 2016, 27 (4) : 550-554.|[4]Ikeda Y, et al. Quantitative evaluation of luminescence intensity from enzymatic luminescence reaction of coelenterazine and analogues. Journal of Photochemistry and Photobiology A: Chemistry, 2020, 394: 112459.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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