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Prazobind

CAT: 0804-HY-118335-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118335-01Size:1 mg
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Description
Prazobind (SZL 49), a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure[1][2][3][4].
CAS Number
107021-36-3
Product Name Alternative
SZL 49
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/prazobind.html
Purity
96.20
Solubility
DMSO : 0.1 mg/mL (ultrasonic; warming)
Smiles
NC1=NC(N(CC2)CCN2C(C3=CC4CCC3C=C4)=O)=NC(C=C5OC)=C1C=C5OC
Molecular Formula
C23H27N5O3
Molecular Weight
421.49
References & Citations
[1]Mante S, et al. The alkylating prazosin analog SZL 49 inactivates both alpha 1A- and alpha 1B-adrenoceptors. Eur J Pharmacol. 1991;208 (2) :113-117. |[2]Tabrizchi R, et al. The effects of losartan and captopril on vasopressor actions of cirazoline in the absence and presence of SZL-49 and nifedipine. J Cardiovasc Pharmacol. 1995 Jul;26 (1) :137-44.|[3]Amobi NI, et al. Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens. Br J Pharmacol. 2002 May;136 (1) :127-35.|[4]Eltze M. Functional evidence for an alpha 1B-adrenoceptor mediating contraction of the mouse spleen. Eur J Pharmacol. 1996 Sep 12;311 (2-3) :187-98.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor

Chemical Information

Szl 49

structure given in first source

CAS Number107021-36-3
PubChem CID4892
IUPAC Name[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2-bicyclo[2.2.2]octa-2,5-dienyl)methanone
Molecular FormulaC23H27N5O3
Molecular Weight421.5
XLogP3
Topological Polar Surface Area93.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity735
SMILES
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC5CCC4C=C5)N)OC
InChI
InChI=1S/C23H27N5O3/c1-30-19-12-17-18(13-20(19)31-2)25-23(26-21(17)24)28-9-7-27(8-10-28)22(29)16-11-14-3-5-15(16)6-4-14/h3,5,11-15H,4,6-10H2,1-2H3,(H2,24,25,26)
InChIKey
MXXRJJCMLRPJOF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Szl 49
CAS: 107021-36-3
CID: 4892
Formula: C23H27N5O3
MW: 421.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight421.5
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass421.21138974
Monoisotopic Mass421.21138974
Topological Polar Surface Area93.8 Ų
Heavy Atom Count31
Formal Charge0
Complexity735
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
sc-208183Prazobind
TRC-P702152-10MGPrazobind-d8
P5661Prazobind (1- (4-Amino-6,7-dimethoxy-2-quinazolinyl) -4- (2-bicyclo[2.2.2]octa-2,5-dienyl-carbonyl) -piperazine, SZL-49)
MBS6049876-01Prazobind (1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-bicyclo[2.2.2]octa-2,5-dienyl-carbonyl)-piperazine, SZL-49)

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